REVVE: Protocolized Intervention for Biofilm-Driven Meibomian Gland Disease
REVVE is an acronym for Recognize, Exfoliate, Vaporize, Vibrate, and Express — the sequenced steps of a protocolized intervention designed to reduce biofilm burden, address inflammation, and restore meibomian gland expressibility. This page explains the scientific rationale, sequencing, and clinical logic of the REVVE protocol. It is intended for clinicians, scientific reviewers, and investors evaluating how Meibum Scientific operationalizes its disease model.
Structure improves repeatability
Dry eye and blepharitis are chronic inflammatory diseases with predictable progression. Episodic or non-standardized interventions often produce inconsistent outcomes because they fail to address disease drivers in a structured, repeatable manner.
The REVVE protocol was developed to introduce consistency, sequencing, and durability into the treatment of biofilm-driven meibomian gland disease.
Non-standardized treatment can leave inflammatory sources partially addressed, leading to variable response.
Protocolization standardizes sequence, reassessment, and interval planning to support durable control.
Sequenced intervention with iterative reassessment
REVVE is a protocolized approach designed to eliminate biofilm, reduce inflammation, and restore meibomian gland expressibility. The protocol emphasizes sequence-dependent intervention and iterative reassessment based on clinical response.
Lid Margin Debridement
The protocol begins with mechanical removal of lid margin biofilm and debris. This step reduces surface bacterial load, limits ongoing toxin release, and prepares the glandular system for deeper intervention.
Reduce surface biofilm burden and debris.
Lower surface load and improve readiness for deeper steps.
Intraglandular Biofilm Disruption
Following surface debridement, targeted intraglandular biofilm disruption is performed. This step addresses biofilm within the glandular structures themselves, where inflammation is sustained and conventional therapies have limited penetration.
Disrupt biofilm within glandular structures.
Address deeper inflammatory sources that are not reachable by surface-only approaches.
Vibrating Thermal Expression
Controlled thermal energy combined with vibration facilitates evacuation of diseased meibum, biofilm remnants, bacteria, and inflammatory byproducts. This step supports restoration of physiologic oil flow and improved gland expressibility.
Evacuate obstructive contents and support oil flow.
Improve expressibility after inflammatory burden reduction.
Repetition until stability, then interval extension
Treatments are typically repeated at defined intervals until consistent expression of clear, healthy oil is observed. Maintenance intervals are then extended based on clinical stability, supporting durable disease control rather than episodic symptom management.
Evaluate expressibility, inflammatory features, and symptom trajectory at each visit.
Continue protocol cycles at defined intervals until stability criteria are met.
Extend intervals based on sustained stability while monitoring for recurrence.
Treatment cadence is individualized. Clinical judgment and patient-specific factors guide interval planning.
Implementation and Inquiry
For clinician and partner inquiries, Meibum Scientific can provide protocol context, education materials, and implementation guidance.
For clinician and partner inquiries.